For decades researchers have debated whether the biological consequences of an individual’s life experiences are reprogrammed from parent to offspring. While some studies report no remarkable effects of such experiences, a growing body of literature has challenged these findings and demonstrated significant aberrations that influence disease risk through the germline from parent to child. (Bohacek and Mansuy, 2013; Szyf, 2015). By now, several cases of cross-generational (parent-child) transmission regarding drugs of abuse have been published, describing behavioral phenotypes and molecular disturbances in the offspring of parents that were exposed to drugs before mating, including cannabinoids (reviewed in (Szutorisz and Hurd, 2015; Vassoler and Sadri-Vakili, 2014; Yohn et al., 2015)). However, most of these studies did not address the impact of gender in the context of naturally occurring cannabinoids such as Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana (Byrnes et al., 2012; Vassoler et al., 2013).
