Our lab has investigated whether recent drinking history or family history of alcohol are associated with differences in adaptation of subjective responses to alcohol during a 2 hour 60 mg/dL BrAC clamp. One report from this study documented an association of heavier recent drinking history with lower initial response and less acute tolerance as reflected by subjective ratings of intoxication and high (Ramchandani et al., 2002). A second report documented an association of a positive family history with higher initial subjective ratings of intoxication, and greater acute tolerance (Morzorati et al., 2002). Family history positive and negative subjects did not differ in recent drinking history (Ramchandani et al., 2002).
