ethanol (1.8 g/kg, not shown). The decreased LORR time with Clic4 overexpression is consistent with results of Fig. 1C showing that higher Clic4 expression correlates with higher blood ethanol levels being required for initiation of rotarod ataxia (decreased sensitivity). These results indicate that the expression level of Clic4 can influence the level of response to high-doses of ethanol in DBA/2J mice, consistent with a role for CLIC proteins in behavioral responses to acute ethanol in mammals.
