The SRE is the most widely-used self-report measure of alcohol sensitivity. However, the SRE’s relative utility in predicting subjective effects has never been directly tested against an alternative self-report measure. The goals of the current study were to evaluate the validity of the ASQ as such an alternative measure. We tested a family of hierarchical models in which SRE and ASQ factor scores were used to predict changes in self-reported stimulation, sedation and intoxication over time following alcohol or placebo consumption. We expected ASQ factor scores to reliably differentiate subjective responses over time for participants who consumed alcohol (but not placebo), such that higher ASQ scores (LS) would predict decreased sedation and subjective intoxication and increased stimulation. Moreover, due to its broader sampling of both stimulation- and sedation-related effects, we also expected the ASQ to provide better fit to the data relative to the SRE in predicting these outcomes.