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Chunk #89 — Online Methods — 8. Clustering of epigenomes reveals common lineages, common properties

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Integrative analysis of 111 reference human epigenomes.
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For each analyzed mark, we calculated Pearson correlation values between all pairwise combinations of reference epigenomes using the mark's signal confidence scores (-log10(Poisson p-value)) within 200bp of the genomic regions deemed relevant for that mark. Relevance of regions is determined by whether a region was called in a particular (mark-matched) chromatin state with posterior probability of > 0.95 in any of the reference epigenomes. For H3K4me1, H3K27ac and H3K9ac we used state Enh, for H3K4me3 state TssA, for H3K27me3 state ReprPC, for H3K36me3 state Tx and for H3K9me3 state Het, unless otherwise noted (all based on the 15-state core model).