(glucosamine-6-phosphate deaminase 2) and COMMD8 (COMM domain-containing protein 8) genes that flank the chromosome 4 GABAA cluster were readily detected in samples in which the four GABAA genes were minimally expressed. Together, these RNA-Seq and qPCR results suggest that the effects of the AD-associated GABRA2 polymorphism on gene regulation are specific for the ~1.4 Mb region containing the chr4p12 GABAA gene cluster.
