Importantly, it is highly significant that 3xTg-AD mice express Tau, APP, and PSEN-1, which our neuroproteomic studies have shown are the main modulators of alcohol-sensitive protein networks within the AMY (Salling et al., 2016) and PFC of mice (Fig. 1). To our knowledge, this innovative transgenic model of AD vulnerability has not been studied in the alcohol field leaving untapped potential for discovering alcohol-induced changes in pathology.
