Chunk #28 — Potential Biological Mechanism of Hippocampal Sensitivity to AUDs: Impact of Altered GluN and GABAR Signaling in the Hippocampus on Adult Neurogenesis — Regulation of Neurogenesis by GABAaRs
maintained (165, 166) as such and proliferation would be reduced (167–169). In the acute absence of alcohol, the facilitation of GABAaR activity would be lost and quiescent cells would be allowed to proliferate, and these effects could result in increase or decrease in cell survival in the days following withdrawal (169–171). However, impaired GABA-ergic receptor function has been shown to restrict morphology of newly born cells (172), which could reduce the number of synaptic connections and network integration required for survival and function of the granule cells and, therefore, result in net reduction of the number of surviving cells during protracted abstinence (171). This finding serves as a potential argument for the reduced survival subsequent to the increased proliferation following withdrawal in dependent animals (171).
