we know of no prior GWAS (Genome-Wide Association Study) of resting state EEG coherence, and only a single previous GWAS of theta inter-trial phase coherence during the P300 window conducted by Malone and colleagues, which identified a region on chromosome 2 (~TEKT4)11. Previous GWAS have examined other EEG measures, including EEG power and P300 amplitude12,13. Our group also conducted an earlier GWAS of event-related theta oscillations during the P300 response, which indicated important variants in KCNJ614; however this result was not confirmed in Malone et al11 with a closely related phenotype. In 2018, Smit et al.15 performed the largest GWAS to date of resting-state EEG oscillatory power across a range of frequencies and identified novel variants in chromosome 3p21.1 for alpha EEG power. In addition, GABRA2 significantly affected beta power, consistent with the known relation between GABAA interneuron activity and beta oscillations16. More recently, a GWAS of resting-state beta EEG power conducted in individuals of African ancestry implicated variants on chromosome 3q267.
