Subjects in the present study had lower rates of endorsement of cannabis use disorders than of alcohol, cocaine, and opioid use disorders. This is likely because the participants were ascertained primarily for genetic studies of opioid, cocaine, and alcohol dependence. Although the composition of our sample was similar to that ofHasin et al. (2012), the prevalence rate of AUDs in our sample was much higher than that in the epidemiologic samples of Shmulewitz et al. (2010),Keyes et al. (2011), andMewton et al. (2011). Thus, findings from the present study complement the findings from studies that compared DSM-IV and DSM-5 using epidemiologic samples in the United States (Agrawal et al. 2011) and Australia (Mewton et al. 2011). Because our study sample was comprised predominantly of individuals with a lifetime SUD, our findings cannot be generalized to the general population.
