Chunk #37 — Discussion — Activation of CB1 receptors within the medial or central nucleus of the amygdala exerts differential effects on stress-induced HPA axis activation
Pharmacological modulation of CB1 receptor signaling within the CeA did not alter the HPA axis response to acute restraint stress. This finding is not entirely unexpected, as the expression levels of FAAH and the CB1 receptor within this part of the amygdala are relatively sparse (Katona et al., 2001; Gulyas et al., 2004). Furthermore, the CeA appears to be more important for HPA axis activation following physiological stressors, rather than psychological stressors, particularly restraint (Prewitt and Herman, 1997; Dayas et al., 1999, 2001).
