Chunk #14 — Epigenesis: The Developmental Cascade of Risk, Heterogeneity of Developmental Course, and Possible Indirect Genetic Effects on the Disinhibition Pathway
In all of this work, predictors of high-trajectory class membership are also the identifiers of the disinhibition/undercontrol pathway: positive SUD family history, parental heavy drinking/AUD, poor parental monitoring and support, early age of onset of alcohol/other drug use, exposure to heavy-drinking peers. The developmentally very early appearance of a high-problem class has also been demonstrated in a trajectory class analysis of disinhibitory behavior over the course of childhood (Jester et al., 2005, 2008). This work, which identified a high disinhibition/disruptive behavior class in a longitudinal study spanning ages 3 to 17 years, not only provides developmental continuity with the older studies; it also indicates very early detectability of the high undercontrol chronic pathway.
