accurate disease risk prediction using polygenic risk scores. The future goal of precision medicine cannot be achieved without genetic association studies in diverse populations. Researchers from COGA are also generating transcriptomic and epigenomic data at single nuclei level from many different regions from post-mortem human brains of alcoholics and controls. Single nuclei transcriptomic analysis in human brain will be extremely useful to understand the role of various cellular lineages in development of AUDs. Genetic studies of AUD are advancing in the right direction and insights revealed will elucidate novel therapeutic targets resulting in better understanding of AUD biology.
