diffusion (i.e., isotropic volume fraction; ISOVF), and tract complexity/fanning (i.e., orientation dispersion, OD). Specifically, we assess associations between alcohol intake (i.e., mean daily alcohol units; one unit = 10 ml or 8 g of ethanol) and imaging derived phenotypes (IDPs) of brain structure (total GMV, total WMV, and 139 regional GMVs), as well as 375 IDPs of WM microstructure (DTI and NODDI indices), using data from 36,678 UKB participants. Our analyses adjust for numerous covariates (see Methods for full list).
