It is tempting to compare these findings on induced human neurons, linking excitability with GIRK2 expression, with the original observations from COGA 55 , 56 , 57 that noncoding KCNJ6 SNPs were associated with activation in theta power during attention, response inhibition and reward processing. However, these studies also raise additional mechanistic questions, such as how noncoding SNPs affect KCNJ6 expression and how they might function in GABA and DA neurons. Many of these questions can be investigated using iPSC‐derived neuron models in future studies.
