regulating individual genes, are located farther from coding sequences and may possibly function as general enhancers. However, without careful experimentation, such as promoter reporter gene assays that would specifically test the enhancer activity of these sequences, it is difficult to predict their actual roles. Future studies could address the relationship between location, allele frequency, and other empirical aspects of creQTLs in larger cohorts and healthy tissue. Collapsing SNPs into a dominant model would permit testing of less common SNPs, as requiring five observations in each genotype essentially restricted our analysis to more common variants.
