Since the CBCL subscale social problems measures a behavioral domain related to autism (65), we investigated if the rs7632287 SNP is associated with autism spectrum syndromes. To do so we turned to the Child and Adolescent Twin Study of Sweden (CATSS, N=1771) sample (66) using parent interviews with the Autism-Tics, AD/HD, and other Co-morbidities inventory (A-TAC) (55). In a recent paper (65), comparing A-TAC and CBCL outcomes, the CBCL social problems scale showed the strongest correlation with the A-TAC autism spectrum score and the autism spectrum symptoms of deficient capacity for social interaction. We therefore hypothesized that there would be a relationship between the rs7632287 SNP and aspects of social behaviors in girls as assessed by the A-TAC. In line with our hypothesis, in girls – but not in boys - the rs7632287 SNP was significantly associated with the A-TAC total autism spectrum score as well as with the social interaction and communication domains in the autism spectrum (Table 5).
