and colleagues (Morzorati et al. 2002) examined both an initial response to alcohol and adaptation to this response in FHP and FHN individuals. These authors reported that, when breath alcohol content (BrAC) was clamped (i.e., maintained) at 60 mg% for approximately 2 hr, FHP individuals reported a greater response to the alcohol challenge at the beginning of the clamp, but their self-reports did not differ from that of FHN individuals at the end of the clamp experiment. This finding suggests that FHP individuals had developed within-session (i.e., acute) tolerance. Although these results appear interesting, the utility of the BAES has been somewhat limited based on lack of usage in large studies in a number of populations, limited range of alcohol doses tested so far, and the fact that the original instrument did not allow for baseline testing and disclosed to subjects that they received alcohol (Rueger et al. 2009).
