while α1 subunit peptide and mRNA are decreased following chronic ethanol administration (Mhatre et al. 1993; Morrow et al. 1992). Therefore, it is clear that adaptation in GABAA receptor subunits expression caused by chronic ethanol administration is not universal across brain regions. The mechanisms that underlie regional differences in the regulation of GABAA receptors by ethanol are unclear but may involve mechanisms to be described in the following sections.
