Chunk #14 — Results — The ischaemic stroke metaGRS has comparable or higher predictive power than established risk factors

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Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.

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As expected, established risk factors were positively associated with incident IS, with hypertension being the strongest risk factor (Supplementary Fig. 7). Notably, the HR of the metaGRS (incident IS HR = 1.25 per s.d.) was similar to that of SBP (incident IS HR = 1.28 per s.d., where the s.d. of SBP was 21.7 mm Hg) and current smoking (incident IS HR = 1.25, s.d. = 0.3) (Supplementary Fig. 7).