The outcome’s prevalence, slightly under 0.5%, is lower than those investigated in our simulation study which was 1% or higher. Among all years for the sample of 500 pilots, the median flight time was 26.62 hours (interquartile range: 24.43-29.16 hours). In the sample size of 500 subjects, one subject reported a flight time of 20,750 hours. This outlier was omitted and imputed as the average of the three previously reported flight hours for the previous six months (300 hours).
