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Chunk #54 — Methods — Estimation of the genetic component of gene expression levels (GReX) — Comparison to large single variant meta-analyses

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A gene-based association method for mapping traits using reference transcriptome data.
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For the top PrediXcan results in the WTCCC, we cross-referenced the SNPs in the prediction models for these genes with the publically available single-SNP meta-analysis summary results. We excluded T1D from this analysis because, to our knowledge, there are no publically available meta-analysis studies of this disease. We used meta-analyses results for systolic and diastolic blood pressure as a proxy for hypertension. For CD, RA, and BD we were able to use meta-analyses for the same diseases (CD47, RA48, and BD31).