suggest that the increase in P1 amplitudes reported in HAP-1 mice, compared to LAP mice, is associated with increases in evoked theta ERO energy, not in alpha/beta ERO energy. These studies suggest that differences in delta and theta ERO measures in mice mirror changes observed between groups at high- and low-risk for alcoholism where changes in EROs were found to be more significant than group differences in P3 amplitudes, further suggesting that ERO measures are more stable endophenotypes in the study of alcohol dependence. Further studies are needed to determine the relationship between the expression of these neurophysiological endophenotypes and the genetic profile of these mouse models. Understanding the relationship between evoked oscillatory activity, phase resetting and ERP responses in mouse models with high and low alcohol preference may provide insight into the brain processes underlying susceptibility to alcohol dependence.
