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Chunk #98 — Online Methods — 10. Clustering of DNaseI-accessible regulatory regions to identify modules of coordinated activity

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Integrative analysis of 111 reference human epigenomes.
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Clusters are visualized (Fig. 7a) by ‘diagonalizing’ when possible. First, ‘ubiquitous’ clusters (defined as having at least 50% of epigenomes with an enhancer/promoter density of > 25%) are shown. Then, the remaining clusters are ordered according to which epigenome has the maximum enhancer density.