We compared our CMC-DLPFC prediXcan associations statistics to COLOC results from our recent study23,24. Briefly, COLOC tests for co-localization between GWAS loci and eQTL architecture. We calculated COLOC probabilities of no-colocalization (“PP3”) and colocalization (“PP4”); we consider PP4 > 0.5 to be significant evidence of colocalization25. We found a significant correlation between prediXcan p-values and PP4 values; rho = 0.35, p = 2.3 × 10-311. Thirty-one genes had ‘strong’ evidence of co-localization between GWAS loci and lead or conditional eQTLs23; of these, 21 were genome-wide significant in our prediXcan analysis (significantly more than expected by chance, binomial p-value = 2.11 × 10−104), and all had p < 1 × 10-4. We identified 40 GWAS loci with no significant prediXcan associations; all of these loci also had strong evidence for no co-localization in our COLOC analysis (median PP3 = 0.936, median PP4 = 0.0027).
