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Chunk #32 — Results — Changes in gene expression in the CeA

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Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.
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There were 34 GO BP categories in the CeA that significantly differed between the water and ethanol groups (Table 1), some of which contained 14 or more genes. Table 2 lists the significant genes in several GO BP categories for the CeA. There were 35 genes in the combined ‘synaptic transmission-GABA signaling’ category, of which 27 had greater expression in the ethanol than the water group (Table 2). In addition to several genes involved in GABA signaling (Gabbr1, Gabra1, Gabrg1, Gabrg2, Gad2), there were genes involved in glutamate signaling (Gria1, Gria2, Grik2, Grik5, Grin3a), as well as synaptic vesicle function (Rab2b, Sanpap, Stx3, Syt10, Vapb) that differed between the ethanol and water groups.