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Chunk #18 — Future directions, including animal model approaches to study the neurobiology of SB

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The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies?
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Future areas of research should include the simultaneous assessment of cognitive and emotional functions, neural activation and genetic polymorphisms, structural and functional connectivity, and pharmacological studies with different ligands. The biological differences between men and women vis-à-vis SB should be investigated, as well as the effects of age (adolescents, adults and elderly). Moreover, a practical model should be developed that includes a correlation between cognitive and neuroanatomical dysfunctions and the various steps of the suicidal process comprising psychological pain, suicidal ideation and the suicidal acts themselves.64, 69