In the fed state, when blood glucose levels are high, glucose is taken up by the liver and rapidly phosphorylated to G6P by glucokinase. G6P is at the crossroads of 4 pathways: it can be broken down via glycolysis towards pyruvate, stored as glycogen, dephosphorylated to glucose, or used in the oxidative arm of the pentose phosphate pathway (PPP) (Figure 1).
