From the drug repurposing analysis using S-PrediXcan results, 287 compounds were significantly correlated with the transcriptional pattern associated with risk for PAU (Supplementary Table 14). Of these 287, 141 medications were anticorrelated with the transcriptional pattern. Of those, trichostatin-a (P = 3.29 × 10−35), melperone (P = 6.88 × 10−11), triflupromazine (P = 7.37 × 10−10), spironolactone (P = 2.45 × 10−9), amlodipine (P = 1.42 × 10−6) and clomethiazole (P = 1.30 × 10−5) reversed the transcriptional profile associated with increased PAU risk, targeting a gene near an independent significant locus in the cross-ancestry GWAS.
