Dick et al. (2006) extended the work on GABRA2 by utilizing children and adolescents recruited from both alcohol dependent COGA patient families and control families obtained from community sources (i.e. dental clinics). Results suggested that individuals carrying at least one A allele of the SNP rs279871, which was significantly over-transmitted to alcohol dependent subjects in the adult COGA sample, were twice as likely to meet the three symptom threshold of DSM-III-R for conduct disorder (CD) (OR 2.0; 95%CI=1.02-3.90). We sought to replicate these findings in families of youth with serious substance and behavior problems and adolescent control families.
