maximum amount of alcohol consumed per occasion and lifetime rates of heavy drinking. They did not find a G × E interaction for rs242938. Dahl et al. examined five SNPs in CRHR1 in a sample of alcohol dependent and control subjects. They found no significant allelic or genotypic associations with alcohol dependence, though it should be noted that the SNPs they examined did not include either rs242938 or rs1876831. Although of potential interest as a moderator of heavy drinking and the risk of AD, further evaluation of both the direct and stress moderating effects of CRHR1 are needed.
