uncorrected analysis (binomial P value of 0.12). Although 12 of the 15 loci are found by all methods to be genome-wide significant at P < 7.2 × 10−8, two known loci33, APOB (with triglyceride) and HNF4A (with HDL), pass the threshold only with EMMAX. In contrast, the locus NR1H3 (with HDL), which is genome-wide significant only with uncorrected analysis, turns out to be the only locus whose association has not yet been replicated by an independent study among the 15 loci.
