A second SNP in the CHRNB3-A6 region–rs6982753- had a nominal p-value with the WAIS Digit Symbol phenotype before multiple test correction and almost passed the multiple test correction (p = 0.009). Interestingly, this SNP has an r2 of 0.91 with rs892413 (β = 0.39, p = 0.008), a SNP that has previously been associated with increased risk for cocaine dependence [17].
