Joint analysis of the NESDA/NTR and QIMR samples yielded p=6.4x10-8 (uncorrected for multiple hypothesis testing) for the non-synonymous SNP rs2522833. This result suggests a specific hypothesis for future studies: an association between genetic variation in PCLO and MDD may be detected only in population-based cases. Thus, it would be premature to exclude PCLO from a role in the etiology of some forms of MDD.
