JT made substantial contributions to the conception and design of the study, assisted with the analysis and interpretation of the statistical data, and revised the manuscript. NS performed the statistical analyses, contributed to the interpretation of the statistical data, and revised the manuscript. VV and FC assisted with statistical analyses, contributed to the interpretation of the statistical data, and revised the manuscript. EB and EL participated in recruiting part of subjects and phenotyping of subjects. ER performed the genotyping analyses. EA made substantial contributions to the conception of the study, and helped to draft the manuscript. All authors read and approved the final manuscript.
