Although estimated quality of imputation for rs2208454 was excellent in most studies (O/E ratio > 0.95), it was poor in CHS (O/E ratio = 0.48). Therefore, rs2208454 was genotyped in CHS. When incorporating this result in the meta-analysis instead of the imputed data, the OR was the same at 0.76 but the p-value smaller at 1.44×10−7.
