Chunk #20 — DISCUSSIONS AND CONCLUSION

Source

KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patterns.

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yes

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0.96Sp = 0.88Sp = 0.90Sp = 0.85Sp = 0.86SerineAcc = 0.76Acc = 0.81––Acc = 0.86Acc = 0.90ThreonineAcc = 0.81Acc = 0.77––Acc = 0.91Acc = 0.93TyrosineAcc = 0.83–––Acc = 0.84Acc = 0.88Histidine–––––Acc = 0.93Overall performance–Acc = 0.76 ∼ 0.91––Acc = 0.87Acc = 0.91SVM, support vector machine; MCL, Markov cluster algorithm; GPS, group-based phosphorylation scoring method; BDT, Bayesian decision theory; MDD, maximal dependence decomposition; HMM, hidden Markov model; CP, coupling pattern; Sn, sensitivity; Sp, specificity; Acc, accuracy.