In total, we looked at 1,706 and 6,068 citations available at PubMed and Google Scholar by December 2012, respectively (Table S10). In doing so, we gathered a total of 59 replication attempts from 38 candidate studies targeting GWAS variants discovered in Europeans (40 and 19 attempts used individuals of European and East Asian ancestry, respectively, see Table S11). Nonetheless, the observed effective replicability rates after accounting for statistical power of attempts gathered from GWAS and non-GWAS studies are very similar in both Europeans and East Asians (93.8% vs. 89.5%; P = 0.20 and 80.6% vs. 88.4%, P = 0.69; respectively). Thus, the inclusion of replication attempts that occur outside from the setting of GWAS should not have affected the patterns of replicability we report in the present study.
