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Chunk #40 — 10. Clinical Use of Cannabinoids to Treat Depression, Anxiety, and Stress — 10.2. Cannabidiol

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Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review.
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Multiple positive effects have been linked to CBD (for recent reviews, see [167,189,198]. These include neuroprotective properties and reported effects as an anxiolytic and antipsychotic agent. Other potential therapeutic benefits attached to CBD include amelioration of symptoms in disorders such as PTSD, bipolar disorder, epilepsy, social phobia, schizophrenia, Parkinson’s disease and more [189]. Preclinical animal models suggest that CBD has beneficial effects by itself as well as reducing or abolishing some negative THC-induced effects, notably at long-term [108,128]. It also shows some benefit in reducing nausea and vomiting [199] and has an anticonvulsant effect, which is a promising potential for use, especially for children with epileptic syndromes [189,200].