Thinning of the corpus callosum occurs in uncomplicated alcoholics and is more prominent in the anterior than posterior regions (Estruch et al. 1997; Pfefferbaum et al. 1996). As with WE and KS, evidence for MBD-like pathology in uncomplicated alcoholism raises the possibility that brain damage occurs on a continuum. The following section examines how brain structures and function respond when drinking stops.
