The current study showed that Wy-14643 and fenofibrate dramatically inhibited elevations of ICAM-1, VCAM-1, and PECAM-1 in the brain after LPS. Since these cellular adhesion molecules are important in leukocyte recruitment to the inflammation focus in the brain, and since recruited leukocytes could release substances that harm neurons, Wy-14643 and fenofibrate might protect neurons by inhibiting the leukocyte recruitment. Consistent with this possibility, Wy-14643 and fenofibrate dramatically decreased the number of NE positive cells around the LPS injection site.
