is well suited to many other genomic data types, including other SNP array platforms and array CGH. In previous work, several other authors have considered conventional HMM-based statistical methods to detect copy number changes using array CGH (23,24) and GeneChip® SNP array data (15,16,25,26). In addition, we present novel extensions including: the ability to combine data from several platforms of differing resolution (combining the Human-1 and HumanHap300 arrays in this case) and the ability to infer CNVs across several samples, which allows for increased precision to detect common regions of CNVs when analysing several individuals.
