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Chunk #30 — Results — Role of CREB in the genomic effects of cocaine in the NAc

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Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
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(see Supplemental Table S12 for complete list) have been implicated previously in cocaine responses and likely contribute to the potent action of these two transcription factors on cocaine-induced behaviors (Carlezon et al., 2005; Nestler, 2008). The list of overlapping ΔFosB and CREB target genes generated here offers a rich array of genes that influence cocaine action at the level of the NAc.