For depressive symptoms, there are 163 candidate SNPs. 115 of them (71%) have the predicted direction of effect on depressive symptoms, 20 are significantly associated at the 5% significance level (19 in the predicted direction), and two remain significant after Bonferroni adjustment. For neuroticism, there are 170 candidate SNPs. 129 of them (76%) have the predicted direction of effect, all 28 SNPs significant at the 5% level have the predicted sign, and four of these remain significant after Bonferroni adjustment (Supplementary Fig. 3 and Supplementary Tables 16 and 17). Two of the four are the SNPs identified in the proxy-phenotype analysis for depressive symptoms.
