like any other large scale experiments, are prone to false negative associations due to the impressive amount of hypothesis tests being performed and a small percentage of low quality SNPs can cause important statistical problems ([11]). These statistical limitations demand that any marker considered associated with a particular disease, specially imputed ones, should be directly genotyped using different genotyping platforms. This conservative procedure is now considered mandatory for the publication of such results. Nevertheless, even the follow-up of a small fraction of positive results from a GWAS involves significant costs.
