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Chunk #36 — Materials and Methods — Construction of whole-brain functional connectivity network

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Network analysis of intrinsic functional brain connectivity in Alzheimer's disease.
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Wavelet analysis was used to construct correlation matrices from the regional fMRI time series data. These matrices described frequency-dependent correlations, a measure of functional connectivity, between spatially-distinct brain regions. Correlation matrices were then thresholded to generate a whole-brain functional connectivity network.