The QQ-plot, Figure 2, shows evidence for association as indicated by the points above the confidence interval in the upper, right corner of the plot. The results show (Table 2) that there are two significant sets associated with AD symptom count at the q-value < 0.10 level and several suggestive sets. Of the results listed in Table 2, only one set involved variants that could potentially affect protein coding (i.e. SLC6A3 POLYPHEN – Damaging sets). Three sets involved regulatory annotations based on chromatin activity classifications and a further six involved other annotations indicative of regulatory potential such as promoter regions, CpG shores, non-coding RNA or enhancer regions. The list of variants in each set listed in Table 2 is provided in Table S4.
