in turn are the ones that are then reported in the literature. However, there are many informal reports of mapping studies that have not identified such exonic mutations, and which consequently lie in abeyance, including (as noted already) the large number of GWA studies that have mapped disease-associated variations to noncoding, presumably regulatory, regions [104]. A reasonable strategy for searching for the relevant variations in these regions may be to focus on sequences that exhibit evolutionary conservation and/or whose expression is altered [162]. Conversely, reverse genetic screens looking for phenotypes associated with ncRNAs might target conserved blocks within them and focus on tissues where they are known to be expressed.
