In conclusion, we evaluated 21 SNPs in 19 loci from recent GWA studies for blood lipids in a U.S. population-based multi-ethnic sample. We found that at five loci, the exact same SNP identified in whites was also associated with lipids in both African-Americans and Mexican-Americans. At 1p13 near CELSR2/PSRC1/SORT1, the strongest new locus identified in GWA studies of LDL cholesterol, the same index SNP was associated with LDL cholesterol in all three ethnic groups, suggesting that this locus is of broad relevance. Our findings set the stage for comprehensive fine-mapping and sequencing efforts across these loci in multiple ethnic groups.
