a critical role in synaptic plasticity and memory. The reintroduction of BAF53b into dorsal hippocampus using adeno-associated virus rescued long-term memory deficits in the Baf53b+/− het mice, providing clear evidence for the role of BAF53b in memory formation in the adult, independent of its role in neuronal development. The rescue effect was specific to the hippocampus-dependent OLM task, further supporting a specific role for BAF53b in adult memory formation.
